Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.
Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Bisphosphonates are beneficial in reducing the risk of vertebral fractures.  Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone ( mg of prednisolone), especially when this is in excess of three months.   The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases.  Alternate day use may not prevent this complication. 
John Daniel Tooz Matuszak was an American football defensive lineman in the National Football League and also an actor. Matuszak was born in Oak Creek, Wisconsin. He attended the University of Tampa and played for their football team. Matuszak also played for various NFL teams--his longest stint of six years having been spent with the Oakland/Los Angeles Raiders--and later joined the Houston Texans of the World Football League, albeit never actually playing. His first major role as an actor was in the 1979 movie "North Dallas Forty" as a football player. He also appeared in the movies "Caveman", "The Ice Pirates", and "One Crazy Summer" but is known for his role in "The Goonies". He also had guest appearances on popular TV shows "Perfect Strangers", "M*A*S*H", "The Dukes of Hazzard", "Hunter", "Silver Spoons", "The A-Team", "1st & Ten", "Miami Vice" and "Cheers". He died on June 17, 1989 aged 38 due to a heart failure.