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In terms of molecular structure, synephrine has a phenethylamine skeleton, with a phenolic hydroxy - group, an alcoholic hydroxy- group, and an N -methylated amino -group. Alternatively, synephrine might be described as a phenylethanolamine with an N -methyl and p -hydroxy substituent. The amino-group confers basic properties on the molecule, whereas the phenolic –OH group is weakly acidic: the apparent (see original article for discussion) pK a s for protonated synephrine are (phenolic H) and (ammonium H).