I used creatine 8 or so years ago, had great gains, ( it was the exact same product then & dont tell me its gotten better becasue its effervescent or some .) But I also had a frequent & uncomfortable need to urinate that was NOT just from consuming extra liquid, but from my kidneys being put on overload & doing damage to them with this stuff. I drank plenty of water, took a little less than the recommended dose & was having the urination problem for years after the use of creatine… I also was very short tempered with my family & young kids at the time I took it as it altered my mood.
I also have a friend who underwent a kidney transplant, that if he didnt get, he would have died . the reason for his kidney failure was creatine & he would tell you to stay far away from it as it almost costed him his life. This stuff is absolutely no good-
Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are